The Arizona Cardinals (1-1) open Week 3 of the 2026 regular season on the road against the San Francisco 49ers (2-0) at Levi's Stadium. Kickoff is set for 4:05 PM EDT on September 27, with the game televised nationally on FOX.

DraftKings lists the 49ers as eight-point favorites at -8.5, with the total set at 47.5 points. The matchup features a 1-1 Arizona squad facing a 2-0 San Francisco team looking to extend its early-season edge at home.