The San Francisco 49ers host the Denver Broncos at Levi's Stadium on October 4, 2026, with kickoff set for 4:25 PM EDT on CBS. The 49ers enter the game with a 3-0 record, sitting atop the NFC West, while the Broncos are 2-1 following their Week 3 victory. DraftKings lists San Francisco as a 3-point favorite with an over/under of 48.5 points.
This marks the 49ers' first home game of October, and they'll look to extend their winning streak against a Broncos team that has shown improvement on both sides of the ball through three weeks. The game carries early-season weight in the NFC playoff race, with San Francisco aiming to remain unbeaten and Denver seeking to prove its 2-1 start is sustainable against a stacked NFC opponent.